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Biologics

Who’s afraid of IgM?

Immunoglobulin M (IgM) is the second most common antibody in humans surpassed only by immunoglobulin G (IgG). The IgM molecule is a pentamer - whereas IgG is a dimer - and with a molecular weight of appr. 900,000 D IgM has more than 5 times the molecular weight of...

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Monoclonals for migraine

Exciting news regarding a new indication for monoclonal antibodies. FDA has approved Aimovig, a product of the Amgen and Novartis Neuroscience Collaboration, for the prevention of frequent, debilitating migraines.  Aimovig is a human immunoglobulin G2 monoclonal...

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Monoclonals for dogs

If your dog needs itch relief, your vet may now offer a drug called Cytopoint. Cytopoint, produced by Zoetis Inc. and available in the US since early 2018, is an engineered (caninized) monoclonal antibody directed against interleukin-31. Interleukin-31 has been shown...

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A novel recombinant protein for treatment of stroke

Stroke is the fifth leading cause of death in the United States and the number one cause of adult disability. Acute ischemic strokes occur when a clot blocks blood flow to the brain. To date, the FDA has approved only one drug treatment, called tissue plasminogen...

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